COVID-19 Supplements: Medical researchers from the Harvard Medical School, University of California-Davis, Virginia Commonwealth University and Institute for Systems Biology, Seattle have discovered that chemical molecules called resolvins which are a type of novel endogenous specialized pro-resolving lipid autacoid mediators (SPMs) could help prevent the cytokine storms caused by the COVID-19 disease.
Resolvins are specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as docosapentaenoic acid (DPA) and clupanodonic acid.
The research was published in the journal journal Cancer & Metastasis Reviews and the study was led by Assistant Professor Dr Dipak Panigrahy and Dr Molly Gilligan, both from Harvard Medical School.
The researchers studied the human body’s robust inflammatory response to the SARS-CoV-2 virus, which is now recognized as a hallmark symptom and observed that severe COVID-19 illness can result in excessive inflammation throughout the body, including the lungs, heart and brain.
Rather than blocking cytokines, medical staff could turn off virus-induced inflammation by broadly activating the body’s natural inflammation-clearing activities.
Resolvins and other SPMs stimulate macrophage-mediated clearance of debris and counter pro-inflammatory cytokine production, a process called inflammation resolution. SPMs and their lipid precursors exhibit anti-viral activity at nanogram doses in the setting of influenza without being immunosuppressive. SPMs also promote anti-viral B cell antibodies and lymphocyte activity, highlighting their potential use in the treatment of COVID-19.
Dr Gilligan told Thailand Medical News, “We are now recognizing the importance of controlling this robust inflammatory response in COVID-19 infection in order to reduce associated organ damage and mortality.
Finding new ways to dampen the body’s inflammatory response to COVID-19 will likely be as important as finding effective antiviral therapies to control COVID-19 infection and reduce life-threatening organ damage. Moreover, these Resolvins have been found to be non-toxic and non-immunosuppressive in ongoing clinical trials for other inflammatory diseases, making them even more promising candidates for rapid clinical translation.”
Among significant findings from the study are:
-A major effect of SARS-CoV-2 infection is a cytokine storm, which is a drastic increase in immune cell production of cytokines;
-COVID-19 disease can cause unchecked inflammation that can cause extensive organ damage, such as lung failure;
-Present therapeutic strategies in COVID-19 focus on inhibiting a single pro-inflammatory cytokine rather than broadly inhibiting the body’s inflammatory response;
-Resolvins or lipid mediators derived from omega-3 fatty acids serve as the body’s natural “stop” signals to inflammation.
The medical researchers found that increasing levels of these resolvins or lipid mediators in the body could be a new therapeutic approach to preventing life-threatening inflammation caused by SARS-CoV-2.
Dr Dipak Panigrahy, an assistant Professor of pathology in Beth Israel Deaconess Medical Center, Harvard Medical School commented, “What is exciting for us is that these lipid mediators that ‘turn off,’ or resolve, inflammation are already in clinical trials for other inflammation-driven diseases, such as eye disease, periodontal disease and pain.The mediators can quickly be applied to turn off inflammation in COVID-19 patients.”
What makes resolvins ideal is that there are basically derived from omega-3 fatty acids that are already proven safe for human consumption, are inexpensive, easily available and consumed.
Thailand Medical News however warns all readers that if anyone suspects that they have contracted COVID-19 disease, do no attempt to self-treat but instead immediately report to local health authorities or a nearby hospital and also prior to consuming any supplements, always check first with a doctor.
When buying dietary or nutritional supplements, avoid brands made in Asia but instead procure brands from the US, UK, Canada or Australia as regulatory standards are more stringent there and quality of supplement products are more better and credible.
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