Ibuprofen is being tested to assess whether or not it can save extreme breathing issues in treatment of COVID-19 patients and reduce the wide variety of people needing remedy in intensive care units.
The study targets to lessen respiration failure with COVID-19, which may decrease the want for more aggressive intervention along with ventilation, and reduce the duration of health center stay.
The leaders of the look at say that this trial will help to refine treatment for COVID-19 as an technique wonderful from either vaccines or anti-viral tablets being researched by means of different groups.
This trial represents an opportunity to formally test promising results from animal models and case studies in patients. If successful this trial will provide evidence for a low cost treatment that could benefit patients in the UK as well as other countries, including lower and middle income countries.– Professor Mitul Mehta, Centre for Innovative Therapeutics (C-Fit), NIHR Maudsley BRC
The drug is a unique method of ibuprofen, that is already certified for use within the UK, and is extensively used for other conditions. The drug differs from fashionable ibuprofen. In lab-based experiments finished by means of the SEEK Group the drug turned into shown to be more effective than standard ibuprofen for treating ARDS.
The LIBERATE trial could be a randomised study, with half of of the recruited patients receiving widespread care and the alternative 1/2 receiving the drug similarly to standard care. The drug may be administered at a completely precise level of the disease, to hospitalised sufferers with confirmed or suspected COVID-19.
LIBERATE is being led at Guy’s and St Thomas’ NHS Foundation Trust by Professor Richard Beale, Consultant in Intensive Care Medicine who says: “As a new illness, there are restrained treatment alternatives for patients with COVID-19. The clinical trial will assess whether this specific method of an established drug advantages sufferers with COVID-19.”
This highly innovative therapeutic approach seeks to rapidly advance a potentially important new treatment. If successful, the global public health value of this trial result would be immense given the low cost and availability of this medicine. The World Health Organisation and European Medicines Agency have highlighted that studies like this are vital in tackling this pandemic.– Professor Matthew Hotopf, Director of the NIHR Maudsley BRC
Professor Steven Williams, Head of Department of Neuroimaging on the Centre for Neuroimaging Sciences at King’s College London, said: “Since SEEK shared their compelling pre-clinical records with us a few weeks ago, the C-FIT team have labored tirelessly to layout and provoke this critical trial. We will now persevere with its implementation and delivery.”
Gregory Stoloff, CEO of SEEK Group, said: “SEEK’s goal has constantly been to bring drugs to sufferers as speedy as possible with safety, efficacy and affordability as key priorities the use of modern and pioneering techniques. This joint venture gives SEEK with get entry to to world renowned research and to the main experts in these therapeutic areas of unmet need. It would be great so as to save lives and improve the environment and restrictions associated with this COVID-19 pandemic.”
This trial has been facilitated by King’s College London’s Centre for Innovative Therapeutics (C-FIT) and a newly fashioned joint mission for repurposing drug treatments with King’s and SEEK – Beta Therapeutics & Diagnostics Health Limited.
The studies is funded by King’s College London’s King’s Together Fund, the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC) and King’s College London Department of Neuroimaging.
COVID-19: Ibuprofen Tested As Treatment To Reduce Symptoms
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